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Free News Articles Home Drugs and Pharmaceuticals Medical Advanced Phase I and Phase II Studies of Targeted Gene Delivery Confirm That Rexin-G Impacts Survival in Chemotherapy-resistant Bone and Soft Tissue Sarcoma (ASCO 2010) Advanced Phase I and Phase II Studies of Targeted Gene Delivery Confirm That Rexin-G Impacts Survival in Chemotherapy-resistant Bone and Soft Tissue Sarcoma (ASCO 2010) Author: Epeius Biotechnologies Corporation
Dateline: San Marino Wholesale Jerseys Free Shipping , California (SAN MARINO, Calif.) | Tue, 01 Jun 2010
freeNewsArticles Story Summary: “SAN MARINO, Calif. -- Epeius Biotechnologies Corporation today announces the results of the clinical trial entitled 'Advanced Phase III Evaluation of Tumor-Targeted Gene Delivery: Intravenous Rexin-G as Stand Alone Therapy for Chemotherapy-resistant Bone and Soft Tissue Sarcoma' at the ASCO Annual Meeting on June 8 Wholesale Jerseys From China , 2010. The presentation will be discussed by Dr. Kristen N. Ganjoo, Stanford University Medical Center, Palo Alto CA.”
A R T I C L E:
Epeius Biotechnologies Corporation (www.epeiusbiotech) today announces the results of the clinical trial entitled "Advanced Phase III Evaluation of Tumor-Targeted Gene Delivery: Intravenous Rexin-G as Stand Alone Therapy for Chemotherapy-resistant Bone and Soft Tissue Sarcoma" at the ASCO Annual Meeting on June 8, 2010. The presentation will be discussed by Dr. Kristen N. Ganjoo Wholesale Jerseys China , Stanford University Medical Center, Palo Alto CA.
STUDY SUMMARY: The goals of the study were to evaluate the over-all safety and efficacy of intravenous infusions of Rexin-G, a tumor-targeted retrovector bearing a cytocidal anti-cyclin G1 construct, in chemo-therapy-resistant bone and soft tissue sarcoma. A Phase II "run-in" component was integrated by adaptive design by continuing treatment if the patient had Grade 1 or less toxicity. Thirty-six patients received escalating doses of Rexin-G intravenously three times a week for four weeks. Analysis of safety showed no dose-limiting toxicity and no cumulative toxicity in patients treated with Rexin-G monotherapy for up to 2 years. Analysis of efficacy revealed a dose-dependent relationship between progression-free survivaloverall survival and Rexin-G dosage (p = 0.02 and 0.002 respectively) which was significant at the 5% statistical level by the log-rank test. Median survival was 11.5 months and one-year survival was 40% in the high-dose groups. These findings indicate that intravenous Rexin-G is safe and well-tolerated with no cumulative toxicity Wholesale Jerseys , and that Rexin-G controls tumor growth, and prolongs progression-free survival and over-all survival times in a dose-dependent manner in patients with chemotherapy resistant bone and soft tissue sarcoma.
About Epeius Biotechnologies:
Epeius Biotechnologies Corporation (www.epeiusbiotech) is a privately held biopharmaceutical company dedicated to the advancement of genetic medicine with the development and commercialization of its lead products, Rexin-G® and Reximmune-C, and its high-performance gene delivery systems.
To learn more about these agents andor ongoing clinical trials Cheap Nike NFL Jerseys , please contact Dr. Erlinda M. Gordon at egordon_@_epeiusbiotech.
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Copyright © 2010 by Epeius Biotechnologies Corporation and Send2Press® Newswire, a service of Neotrope® - all rights reserved. Information believed accurate but not guaranteed. Sourced on: freeNewsArticles.
• Web Image (72dpi): https:www.send2pressmediaboom10-0504-epeiusbio_72dpi.jpg
• Story Title: Advanced Phase I and Phase II Studies of Targeted Gene Delivery Confirm That Rexin-G Impacts Survival in Chemotherapy-resistant Bone and Soft Tissue Sarcoma (ASCO 2010)
• REFERENCE KEYWORDSTERMS: Intravenous Rexin-G, San Marino, California Cheap NFL Jerseys , ASCO Annual Meeting, Drugs and Pharmaceuticals, Medical, Cheap Jerseys From China , SAN MARINO, Calif..
IMPORTANT NOTICE: some content which is considered "old" or "archival" may reference an event which has already occurred; some content possibly considered "advertorial" may also reference a promotion or time-limitedsensitive offering, and in all of these instances certain material may no longer be valid. For notably stale content, you should directly contact the companyperson mentioned in the text (Epeius Biotechnologies Corporation); this site cannot assist you with information about productsservices mentioned in the news article Cheap Jerseys , nor handle any complaints or other issues related to any personcompany mentioned or promoted in the above text. Information believed accurate but not guaranteed as of original date of story [Tue, 01 Jun 2010 12:29:15 GMT].
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